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Article|Articles in Press, 100005

Predictors of genetic risk recall among participants of a randomized controlled precision prevention trial against melanoma

Published:January 07, 2023DOI:https://doi.org/10.1016/j.gim.2023.100005
Predictors of genetic risk recall among participants of a randomized controlled precision prevention trial against melanoma
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      Abstract

      Purpose

      Inherited variation at MC1R imparts low to moderate risk of melanoma. Research on genetic risk recall, factors predicting recall, and whether recall influences adoption of preventive behaviors is limited.

      Methods

      Participants (n=447) enrolled in a melanoma precision prevention trial were provided MC1R risk information (average or higher) and asked to recall their genetic risk after 6 and 12 months. Predictors of recall were identified using backwards stepwise selection. Intervention effects were reassessed after stratifying by recall.

      Results

      Higher-risk participants were two to three times more likely to misremember or not recall than average-risk participants. Misremembering was almost exclusively observed among higher-risk participants. Among average-risk participants, lower health numeracy and not completing the telephone follow-up were associated with not recalling or misremembering. Among higher-risk participants, lower education was associated with not recalling, and lower perceived comparative chance of getting melanoma was associated with misremembering. In general, higher-risk participants who correctly recalled had modestly stronger intervention effects on sun protection behaviors than those who misremembered or did not recall.

      Conclusion

      Future studies should examine different strategies to increase genetic risk recall, which may result in improved behavioral outcomes, especially among participants with lower education and health numeracy.

      Keywords

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      Article info

      Publication history

      Accepted: December 21, 2022
      Received in revised form: December 20, 2022
      Received: July 8, 2022

      Publication stage

      In Press Accepted Manuscript

      Footnotes

      4 Department of Health and Behavioral Outcomes, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, US

      Conflict of Interest Statement:

      The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

      This research was funded by the American Cancer Society (RSG-14-162-01-CPHPS) and was supported in part by the Biostatistics and Bioinformatics Shared Resource, Molecular Genomics Core, and Tissue Core, at the H. Lee Moffitt Cancer Center and Research Institute, a comprehensive cancer center designated by the National Cancer Institute and funded in part by Moffitt’s Cancer Center Support Grant (P30 CA076292).

      Identification

      DOI: https://doi.org/10.1016/j.gim.2023.100005

      Copyright

      © 2023 American College of Medical Genetics and Genomics. Published by Elsevier Inc. All rights reserved.

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